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Central Line-Associated Bloodstream Infections (CLABSI)

Central line-associated bloodstream infections (CLABSI), are a type of healthcare-associated infection (HAI), and is associated with significant morbidity, mortality, and costs. As many as 28,000 patients die from CLABSI annually in U.S. intensive care units. AHRQ has tools and research for healthcare professionals to prevent and reduce CLABSI.

Tools for Reducing Central-Line Associated Bloodstream Infections
These tools will help each unit implement evidence-based practices and eliminate central line-associated blood stream infections (CLABSI). When used with the CUSP (Comprehensive Unit-based Safety Program) Toolkit, these tools dramatically reduced CLABSI rates in more than 1,000 hospitals across the country.

PSNet
AHRQ's PSNet (Patient Safety Network) highlights research on CLABSI. Included studies range from the use of health care simulation and unit-based nurse educators to reduce CLABSI to studies showing safety programs leading to marked reduction in CLABSI and related cost savings.

Innovations Exchange
AHRQ's Innovations Exchange explores CLABSI-related innovations.

Eliminating CLABSI, A National Patient Safety Imperative: Final Report
This report summarizes the results and lessons learned from an AHRQ-funded national effort to prevent CLABSI.

Eliminating CLABSI, A National Patient Safety Imperative: Neonatal CLABSI Prevention
This report on AHRQ's national neonatal CLABSI prevention project provides an overview of the project and its accomplishments.

High-Performance Work Practices in CLABSI Prevention Interventions
This report, based on interviews with participants in AHRQ's CUSP national implementation project, describes practices and "success factors" for reducing and eliminating CLABSI in health care facilities.